Research regarding design automation that integrates artificial intelligence (AI) into computer-aided design (CAD) and computer-aided engineering (CAE) is actively being conducted. This study proposes a deep learning-based CAD/CAE framework that automatically generates three-dimensional (3D) CAD models, predicts CAE results immediately, explains the results, and verifies the reliability. The proposed framework comprises seven stages: (1) two-dimensional (2D) generative design, (2) dimensionality reduction, (3) design of experiment in latent space, (4) CAD automation, (5) CAE automation, (6) transfer learning, and (7) visualization and analysis. The proposed framework is demonstrated through a road wheel design case study and indicates that AI can be practically incorporated into end-use product design. Using this framework, it is expected that industrial designers and engineers can jointly review feasible engineering 3D CAD models created by AI and select the best design for the market in the early stages of product development. In addition, because the proposed deep learning model can predict CAE results based on 2D disc-view design, industrial designers can obtain instant feedback regarding the engineering performance of 2D concept sketches.